Lake Manzala is a highly dynamic aquatic system that has undergone considerable physical, chemical and biological changes during the past century. Many studies have been conducted to describe the ecology of the lake; however, none of the previous studies has been implemented to protect the continuous damage and restoration of Lake Manzala. The present work assesses and monitors the environmental conditions in Lake Manzala to identify the trends of environmental changes by integrating field information, remote sensing data and Geographic Information Systems (GIS). Remotely sensed data can be used as a tool to detect, monitor and evaluate changes in ecosystems to develop management strategies for ecosystem resources reducing reliance on field data in the future particularly for water quality assessment and monitoring of inland water bodies. Using GIS software (Arc-GIS) gives the ability to link spatial data with descriptive information about a particular feature on a map.