This book illustrates the importance of microbiome interactions in sustainable agriculture and the environment. The chapters of the book provide information pertaining to the vast diversity of microbiomes in many ecosystems and their functional dynamics. The book also discusses bioremediation, space microbiomes, geo microbiomes, coral microbiomes, antibiotic resistomes, and rhizomicrobiome. It also sheds light on the complex syntrophic and other symbiotic interactions between bacteria, protists, plants, and certain animals in agricultural and environmental systems. The book, in turn, provides an understanding of the adaptation, resilience, and evolution of microbial ecosystems. Further, the chapters cover metagenomics analysis of microbiomes of a novel or extreme environments, microbial resilience or temporal fluctuations, symbiosis and co-evolution of the microbiome, and novel microbial interactions in agriculture and environment. Finally, the book elucidates a comprehensive yet representative description of complex structural and functional diversity within the plant and environmental microbiomes to reveal their immense potential. This book covers United Nations Sustainable Developmental Goal 2 towards Zero Hunger.