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Transporters in Drug Development by Yuichi Sugiyama, Hardcover | Indigo Chapters
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Coles
Transporters in Drug Development by Yuichi Sugiyama, Hardcover | Indigo Chapters
From Yuichi Sugiyama
Current price: $248.50
Coles
Transporters in Drug Development by Yuichi Sugiyama, Hardcover | Indigo Chapters
From Yuichi Sugiyama
Current price: $248.50
Loading Inventory...
Size: 1 x 9.25 x 15.16
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Transporters in Drug Developmentexamines how membrane transporters can be dealt with in academic-industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples ofin vitrocharacterization of single transporters in the intestines, liver and kidneys as well as characterization of substrate overlap between various transporters. Furthermore, probes and biomarkers are suggested for studies of the transporters' impact on the pharmacokinetics of drug substrates/candidates interacting on transporters. The challenges of translatingin vitroobserved interaction of transporters intoin vivorelevance are explored, and the book highlights perspectives of applying targeted proteomics and mechanistic modeling in this process. | Transporters in Drug Development by Yuichi Sugiyama, Hardcover | Indigo Chapters