Recently ISIS has been on a rampage seeking the destruction of all those who do not accept their radical brand of Islam. The motivation of ISIS comes from one of the only prophecies ever given by the Prophet Muhammad. Understanding this prophecy is crucial when trying to make sense of the actions of ISIS. Amazingly the Bible foretells the fate of ISIS and the power structure behind their quest for world dominion. In this book, the following critical events are explained in detail, including: 1. The power behind a revived Islamic Empire and Muhammad's end-time prophecy. 2. The astounding fate awaiting ISIS based on biblical prophecies. 3. The identity of the man and nation that will seize control of the Islamic world after ISIS has been defeated. 4. The nation the antichrist arises from and how he comes to power. 5. The key event that sets end-time events into motion. 6. The possible fate awaiting the pope and the Vatican. 7. The details of a reverse 9/11 that struck an Islamic nation in September of 2015. 8. How the reverse 9/11 is a harbinger of the fate awaiting all those who will control the Islamic power structure. The Rise and Fall of ISIS and Those Who Will Lead the Islamic Caliphate explains all of these events and broadens our perspectives in the discussion of end-time events from biblically based teachings and the annals of history.