A range of sciences was taught in the Platonist schools of late antiquity (third to sixth centuries) with the purpose of leading the human soul up to a divine life. This curriculum constituted so to speak a ladder of the sciences. The ways in which these sciences were newly interpreted in this context have not, however, been fully appreciated. This volume brings together selected essays, some translated into English for the first time, which show how a new vision of these disciplines and sciences was reached as part of a Platonist philosophical education. They cover a wide range of topics, from rhetoric, ethics and politics to mathematics, music and metaphysics, and discuss the work of various philosophers. Dominic O'Meara is considered one of the foremost scholars of Platonism and this book provides readers with an indispensable tool for accessing his most important scholarship in this area.