IAU Symposium 391 showcases cutting-edge research inspired by the James Webb Space Telescope, as presented during the first IAU General Assembly on African soil. This volume captures the pioneering science of galaxy formation, cosmic reionization, stellar evolution, and early universe dynamics, with contributions addressing topics such as metallicity in primordial galaxies, early Lyman-α emitters, and massive quiescent galaxies at high redshifts. Innovative approaches such as nebular emulators and advanced simulations offer fresh insights into clumpy galaxy formation, thin and thick disk structures, and stellar feedback mechanisms. Special focus is given to unexpected findings, such as unusual chemical abundances and insights from the synergy between JWST and complementary observatories like ALMA. These proceedings highlight the latest breakthroughs in astronomy and the collaborative efforts of scientists worldwide to uncover the secrets of our cosmic origins.