Stem cells play a pivotal role in periodontal regeneration due to their unique ability to transform into various specialized cell types. In periodontal therapy, these cells hold immense promise as they can differentiate into specific tissues like bone, periodontal ligament, and cementum, crucial for repairing and regenerating damaged structures in the gums and supporting bones. Researchers explore different sources of stem cells, including dental pulp, periodontal ligament, and even adipose tissue, harnessing their regenerative potential to combat periodontal diseases. These cells are manipulated and guided to differentiate into the required cell types, promoting tissue repair and regeneration. Stem cell-based therapies offer a futuristic approach in addressing periodontal issues by promoting natural regeneration and potentially revolutionizing treatment strategies for gum diseases and bone loss associated with periodontitis. This comprehensive book serves as an exhaustive and meticulous presentation of stem cell therapies, elucidating their pivotal role in periodontal regeneration while exploring diverse sources of these cells.