Karen and Jack thought they had defeated the evil that tried to destroy humankind. But now there's something even darker, and more sinister in their small town. Mutilated bodies have been showing up with evidence of a werewolf behind the murders, making Karen a suspect in the grisly slayings. The townsfolk that once loved Karen now fear her. The Pack must discover the truth behind the murders, win back the trust of the small town and face the new evil that is threatening not only the world's reality, but the destiny of the universe. Time is running out and Pandora's Box awaits the ultimate showdown to determine everyone's fate. Some will live. Some will die. And one will become the Son of a Bitch.