This book is the second volume of a two-volume book set which introduces software-defined chips. In this book, the programming model of the software-defined chips is analyzed by tracing the coevolution of modern general-purpose processors and programming models. The enhancement in hardware security and reliability of the software-defined chips are described from the perspective of dynamic and partial reconfiguration. The challenges and prospective trends of software-defined chips are also discussed. Current applications in the fields of artificial intelligence, cryptography, 5G communications, etc., are presented in detail. Potential applications in the future, including post-quantum cryptography, evolutionary computing, etc., are also discussed. This book is suitable for scientists and researchers in the areas of electrical and electronic engineering and computer science. Postgraduate students, practitioners and professionals in related areas are also potentially interested inthe topic of this book.