In this issue of Medical Clinics of North America , guest editor Dr. Susan Tuddenham brings her considerable expertise to the topic of Sexually Transmitted Infections . STIs are on the rise in the United States, and concerns for developing drug resistance and new and emerging infections may complicate management. In this issue, top experts in the field provide updates on some of the most important issues in STI diagnosis and management, highlighting new information and practical approaches relevant to primary care practice.