In this issue of Clinics in Chest Medicine , guest editors Dr. John P. Reilly brings his considerable expertise to the topic of Sepsis . Leading experts provide in-depth discussions on fluids, vasoactives, and resusitation targets in septic shock; beyond lactate: biomarkers in sepsis; principals of antimicrobial administration in sepsis; steroids in sepsis; pediatric sepsis; immunology of sepsis; and more.