This volume explores the governance and management of science, technology, and innovation (STI) in relation to social inclusion and sustainability, highlighting its goal, challenges, and opportunities. Divided into two sections, it addresses the goals and institutional arrangements around sustainable development in the context of Latin American countries as well as the challenges of developing absorptive STI capacities for inclusion in the higher education institutions and systems. The chapters tackle the important role of citizen science, science diplomacy, peace building, mission-oriented policies, public innovation, institutional entrepreneurs, and policy networks. Researchers and scholars will find an opportunity to better grasp several topics and methodologies in knowledge development in the governance of STI. This interdisciplinary work presents original research on science, technology and innovation policy and governance studies in an understudied region.