The comparative or connected study of localized intellectual traditions poses special challenges to the global turn in medieval studies. How can we enable conversations across language groups and intricate cultural formations, as well as disciplines? Practices of commentary offer a compelling opportunity: their visual layouts reveal assumptions about the relative status of text and gloss, while interpretive interlinear or marginal prompts capture the dynamic relationships among generations of teachers, students, and readers. The material traces of manuscript usage—from hastily scrawled marginal notes to vivid rubrication—illuminate the shared didactic and communicative practices developed within scholarly communities. By bringing together researchers working on specific cultures and discourses across Eurasia, this volume moves toward a global account of premodern commentary traditions.