In this issue of Medical Clinics of North America , guest editor Dr. Irene Ma brings her considerable expertise to the topic of Point-of-Care Ultrasound in Clinical Care . Top experts describe commonly accepted applications in point-of-care ultrasound (POCUS) and incorporate approaches to integrated POCUS in the assessment of the common medical conditions. Articles also discuss the potential pitfalls and limitations in the use of POCUS and describe the infrastructure and educational elements necessary to support its practice.