Redirection of the focus of epilepsy treatment from preventing the development of epilepsy to preventing epileptic seizures by the International League Against Epilepsy (ILAE) in 2021 results in major changes in the theory, basic principles and expected purposes of pharmacological therapy of epilepsy. Adapting to the change, this book clarifies the theory, significance, methods, principles and precautions regarding antiepileptic seizures from a new perspective. Divided into  nine chapters, this book introduces the new approach toward epileptic seizures, treatment theory, medications, treatment principles, clinical applications, adverse reactions and so on. The treatment of epilepsy comorbidities and methods for terminating status epilepticus, which are rarely covered in previous drug treatment publications, are described in details. It will be a helpful for practitioners in neurology, neurosurgery, emergency care and critical care medicine.