This book constitutes the refereed conference proceedings of the 15thInternational Conference on Performance Evaluation Methodologies and Tools, VALUETOOLS 2022, held in November 2022. Due to the safety concerns and travel restrictions caused by COVID-19, VALUETOOLS 2022 took place online in a live stream.The conference provides a world-leading and multidisciplinary venue for researchers and practitioners in diverse disciplines such as computer science, networks and telecommunications, operations research, optimization, control theory and manufacturing.The 18 full papers were carefully reviewed and selected from 47 submissions and are grouped in thematically as following: game theory; queueing models; applications; retrial queues; performance analysis and networking; distributed computing.