This book presents cutting-edge papers and perspectives on the transport of oxygen to tissues by scientists in a multitude of disciplines such as biochemistry, engineering, mathematics, medicine, physics, physiology, veterinary and complementary medicine. The book is composed of the following 7 parts: 50th Anniversary, Brain, Clinical applications, Methods and techniques, Tumor Oxygenation, Tissue oxygenation and Muscle. The articles in this book have been presented at the 50th annual meeting of the International Society on Oxygen Transport to Tissue (ISOTT 2023). Academics, clinical and industry researchers, engineers, as well as graduate students who are interested in oxygen transport to tissue will find this book a great reference and a useful learning resource.