This book constitutes the refereed proceedings of the 22nd Asia Simulation Conference on Methods and Applications for Modeling and Simulation of Complex Systems, AsiaSim 2023, held in Langkawi, Malaysia, during October 25-26, 2023. The 77 full papers included in this book were carefully reviewed and selected from 164 submissions. They were organized in topical sections as follows: Modelling and Simulation, Artificial intelligence, Industry 4.0, Digital Twins Modelling, Simulation and Gaming, Simulation for Engineering, Simulation for Sustainable Development, Simulation in Social Sciences.