The cell-matrix interaction is a fundamental aspect of cellular biology. It involves the dynamic relationship between cells and the extracellular matrix (ECM). The ECM is a complex network of proteins and polysaccharides that provides structural and biochemical support to surrounding cells. This interaction is crucial for numerous physiological processes, including cell adhesion, migration, proliferation and differentiation. Cells interact with the ECM through specialized receptors, such as integrins, which transmit signals that influence cellular behavior and function. Understanding cell-matrix interactions is pivotal in various fields, including tissue engineering, regenerative medicine, and cancer research. In tissue engineering, mimicking the natural cell-matrix environment is essential for creating functional artificial tissues. Ongoing research in this area promises to unlock new therapeutic strategies for a range of diseases. Cell-matrix interaction is an upcoming field of science that has undergone rapid development over the past few decades.This book includes some of the vital pieces of work being conducted across the world, on various topics related to cell-matrix. It aims to equip students and experts with the advanced topics and upcoming concepts in this area.