Digital transformation has profoundly affected organizations and value chains in cultural production at the global level. The volume focuses on this change by looking at the knowledge, skills, and competencies (KSC) of the labor force in the cultural and creative industries (CCI) in Italy. The contribution of the research is twofold. On the one hand, the book offers a detailed map of the KSC of creative and cultural professions and workers, on the other hand, it identifies relevant gaps between supply and demand across different cultural sub-sectors and typologies of workers. The study adopts an original methodology that implements a Natural Language Processing (NLP) approach to the analysis of education, experiences, and accomplishments contained in CVs. The result of the mapping exercise based on the algorithm shows how managerial and digital skills are increasingly crucial in the CCI in combination with creative skills. The Italian labor market in these industries seems characterized not only by a growing symbiosis between creative, digital, and managerial KSC but also by a convergence of CCI sub-sectors, whose boundaries get increasingly blurred and permeable. Finally, comparing the supply and demand of KSC, the book provides managers, practitioners, policymakers, and educational institutions with a comprehensive overview of the new KSC needed in CCI.