biologyinneuronalprocessesandinbraindisorders. BartdeStrooper YvesChristen v Acknowledgments The editors wish to thank Jacqueline Mervaillie and Sonia Le Cornec for the organizationofthemeetingandMaryLynnGagefortheeditingofthebook. vii Contents Pro?lingthemicroRNAs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 KennethS. Kosik, ThalesPapagiannakopoulos, NaXu, KawtherAbu-Elneel, TsunglinLiu, andMinJeongKye TheWideVarietyofmiRNAExpressionPro?les intheDevelopingandMatureCNS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 MarikaKapsimali InteractionsbetweenmicroRNAsandTranscription FactorsintheDevelopmentandFunction oftheNervousSystem . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 DavidJ. Simon AmicroRNAFeedbackCircuitinMidbrainDopamineNeurons . . . . . . . . . 27 AsaAbeliovich Fine-tuningmRNATranslationatSynapseswithmicroRNAs . . . . . . . . . . . . 35 GerhardM. Schratt NeuronalP-bodiesandTransportofmicroRNA-Repressed mRNAs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45 FlorenceRage CrosstalkbetweenmicroRNAandEpigeneticRegulation inStemCells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 57 KeithSzulwach, ShuangChang, andPengJin microRNAsinCNSDevelopmentandNeurodegeneration: InsightsfromDrosophilaGenetics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 69 StephenM. Cohen ix x Contents DrosophilaasaModelforNeurodegenerativeDisease: RolesofRNAPathwaysinPathogenesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 79 NancyM. Bonini microRNAsinSporadicAlzheimer'sDiseaseandRelated Dementias . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 91 Se´bastienS. He´bert, WimMandemakers, AikateriniS. Papadopoulou, andBartDeStrooper microRNADysregulationinPsychiatricDisorders . . . . . . . . . . . . . . . . . . . . . . . . 99 BinXu, JosephA. Gogos, andMariaKarayiorgou Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 119 Contributors Abeliovich Asa Columbia University Medical Center, 630 West 168th Street, Room15-405, NewYork, NY10032, USA, aa900@columbia. edu Abu-ElneelKawther NeuroscienceResearchInstitute, DepartmentofMolecular CellularandDevelopmentalBiology, UniversityofCaliforniaSantaBarbara, USA BoniniNancyM. UniversityofPennsylvania, 306LeidyLaboratories, Depa- mentofBiology, Philadelphia, PA19104, USA, nbonini@sas. upenn. edu Chang Shuang Department of Human Genetics, Emory University School of Medicine, Atlanta, GA30322, USA CohenStephenM. TemasekLifeSciencesLaboratoryLimited, 1ResearchLink National University of Singapore, 117604 Singapore, SINGAPORE, steve@ tll. org. sg DeStrooperBart Centerforhumangenetics, K. U. LeuvenandDepartmentof molecularanddevelopmentalgenetics, VIBLeuven, BELGIUM GogosJosephA. DepartmentofPhysiology&CellularBiophysicsandDepa- mentofNeuroscience, ColumbiaUniversity, NewYork, USA He´bert Se´bastien S. Centre de Recherche du CHUQ (CHUL), Axe Neur- ciences, Universite´Laval, De´partementdeBiologieme´dicale, 2705Boul. Laurier, LocalRC-9800, Que´bec, Qc, Canada, sebastien. hebert@crchul. ulaval. ca JinPeng DepartmentofHumanGeneticsandGraduatePrograminGeneticsand MolecularBiology, EmoryUniversitySchoolofMedicine, Atlanta, GA30322, USA, pjin@genetics. emory. edu ´ ´ ´ ´ KapsimaliMarika INSERMU784, GenetiqueMoleculaireduDeveloppement, ´ Ecole Normale Superieure, 46 rue d´Ulm, 75230 PARIS Cedex 05 FRANCE, kapsimal@biologie. ens. fr xi xii Contributors Karayiorgou Maria Columbia University, Department of Psychiatry, 1051 RiversideDrive, Unit#28, NewYorkNY10032, USA, mk2758@columbia. edu Kosik Kenneth S. Neuroscience Research Institute, Department of Molecular Cellular and Developmental Biology, University of California Santa Barbara, BiologyII, Room6139A, SantaBarbara, CA93106, USA, kosik@lifesci. ucsb. | Macro Roles for MicroRNAs in the Life and Death of Neurons by Bart De Strooper, Hardcover | Indigo Chapters