This volume constitutes the refereed proceedings of 10th International Conference on Machine Learning and Soft Computing, ICMLSC 2026, held in Osaka , Japan during February 4&6, 2026.The 54 full papers included in thisbook were carefully reviewed and selected from 132 submissions. They were organized in topical sections as follows: Machine Learning Theory and Intelligent Computing in Multi scenario Applications; Key Technologies of Perception based Computer Vision and Digital Image Processing; Intelligent Information Processing and Decision Optimization Empowered by Artificial Intelligence Technology; Network and Information Security Protection Strategy; Design of Intelligent Systems and Robust Control Methods.