Based on the importance of human beings as creators and managers of knowledge towards the achievement of sustainability in the current digital age, this book is an effort to present many studies taking individuals as centers of knowledge and starting points for environmental, social, and economic development. From various theoretical and empirical studies developed by researchers from Mexico, Colombia, and Brazil, this book presents, in an ordered sequence, the individual as the creator of knowledge, the role of human beings as knowledge managers with and for sustainability, the opportunities for knowledge sharing in virtual research collaborations for sustainability, and the advantages and disadvantages with and for sustainability from a human-centered perspective in the digital era. Moreover, this text describes the antecedents of competitive advantage in a sustainable cooperative network, knowledge management in technology projects, an empirical study of knowledge management of tutorial intervention, a model of processes and knowledge management to increase competitiveness, the role of Information and Communication Technologies (ICT) for managing sustainable practices, finishing with knowledge management trends with and for sustainability, from a human-centered perspective in the digital era. Offering an innovative approach, this book seeks to expand the understanding of the theme of knowledge management and sustainability from the perspective of the human resource as a generator of knowledge. There is mounting focus on knowledge-intensive work and sustainable development in the corporate world. In light of these trends, this edited volume will be of value to researchers, academics, professionals, and advanced students in the fields of management, environment and sustainability, and development studies.