This two-volume set constitutes the refereed proceedings of the First EAI International Conference on Intelligent Systems and Machine Learning, ICISML 2022, held in Hyderabad, India, in December 16-17,2022. The 75 full papers presented were carefully reviewed and selected from 209 submissions. The conference focuses on Intelligent Systems and Machine Learning Applications in Health care; Digital Forensic & Network Security; Intelligent Communication Wireless Networks; Internet of Things (IoT) Applications; Social Informatics; and Emerging Applications.