This volume shares and makes accessible new research lines and recent results in several branches of theoretical and mathematical physics, among them Quantum Optics, Coherent States, Integrable Systems, SUSY Quantum Mechanics, and Mathematical Methods in Physics. In addition to a selection of the contributions presented at the "6th International Workshop on New Challenges in Quantum Mechanics: Integrability and Supersymmetry", held in Valladolid, Spain, 27-30 June 2017, several high quality contributions from other authors are also included. The conference gathered 60 participants from many countries working in different fields of Theoretical Physics, and was dedicated to Prof. Véronique Hussin-an internationally recognized expert in many branches of Mathematical Physics who has been making remarkable contributions to this field since the 1980s. The reader will find interesting reviews on the main topics from internationally recognized experts in each field, as well as other original contributions, all of which deal with recent applications or discoveries in the aforementioned areas.