From biblical times to the onset of the Black Death in the fourteenth century, leprosy was considered the worst human affliction, both medically and socially. Only fifty years ago, leprosy, or Hansen’s disease, was an incurable infectious illness, and it still remains a grave global concern. Recently, leprosy has generated attention in scholarly fields from medical science to the visual arts. This interdisciplinary art-historical survey on lepra and its visualization in sculpture, murals, stained glass, and other media provides new information on the history of art, medicine, religion, and European society. Christine M. Boeckl maintains that the various terrifying aspects of the disease dominated the visual narratives of historic and legendary figures stricken with leprosy. For rulers, beggars, saints, and sinners, the metaphor of leprosy becomes the background against which their captivating stories are projected.