The Clinical Research Institute of Montreal, inaugurated in April 1967, intro- duced a new concept of organization of clinical research in teaching medical centers. Adjacent to the Hotel-Dieu Hospital, a major teaching hospital of the University of Montreal, the "professional" or career clinical investigators were grouped under one roof with common auditorium, seminar rooms, instruments rooms, cold rooms, experimental surgical rooms and illustration department, with administration, accounting division and machine shops at the service of the research workers. Besides its large multidisciplinary team working on various aspects of hyper- tension, the Institute includes research teams in the following fields: 1) neuro- biology and Parkinson's disease, 2) lipids and atherosclerosis, 3) molecular biology, 4) immunochemistry, 5) pituitary polypeptides and proteins, 6) nutrition and 7) clinical pharmacology of new drugs. Research is financed entirely by grants obtained from accredited agencies, mostly from the Medical Research Council of Canada. These grant monies constitute about 50 % of the entire budget of the Institute while the other half for administration, maintenance and physical facilities is financed through the support of the Ministry of Social Affairs of Quebec.