This book contributes to the debate on humanism in AI by providing a, so far lacking, comprehensive account of the significant challenges posed by AI to organizations from a humanistic perspective. It does so in two ways: by discussing ethical challenges of AI using humanistic assumptions, normative implications, and underpinning theoretical stances and by focusing on those challenges that can be considered well suited to be tackled from a humanistic perspective as they are more urgent for humanistic-led organizations, as well as those willing to become so. This new perspective allows for new and important discussions, making the book an important read for philosophers of technology and AI.