The two-volume set LNCS 12765-12766 constitutes the refereed proceedings of the thematic area Human Interface and the Management of Information, HIMI 2021, which was held as part of HCI International 2021 and took place virtually during July 24-29, 2021. The total of 1276 papers and 241 posters included in the 39 HCII 2021 proceedings volumes was carefully reviewed and selected from 5222 submissions. The papers included in the HCII-HIMI volume set were organized in topical sections as follows: Part I: Information presentation; visualization and decision making support; information in VR and multimodal user interfaces; Part II: Learning in information-rich environments; supporting work, collaboration and design; intelligent information environments.