This book analyzes how universities in the Greater Bay Area in South China could work together for promoting innovation-centric entrepreneurship, research and knowledge transfer, as well as establishing a leading higher education hub in China mainland. This book brings together leading scholars from history, higher education, sociology, city and urbanism, and development studies, to analyzing the role of higher education, entrepreneurship, and talent hub from historical, comparative, and international perspectives. This book also shares different development experiences of Tokyo, Florida, and New York Bay economies and how higher education has supported their success stories.