In this issue of Cardiology Clinics, guest editor Dr. Asad Ghafoor brings his considerable expertise to the topic of Heart Failure with Reduced Ejection Fraction. Top experts in the field cover issues such as choosing temporary mechanical support in cardiogenic shock; sequencing in quadruple therapy for HFrEF; the war against heart failure hospitalizations: remote monitoring and the case for expanding criteria; the uncertain benefit from ICDs in nonischemic cardiomyopathy; frailty and its spectrum of implications in HFrEF; and more.