This guidance note is designed to help developing member countries of the Asian Development Bank strengthen their health systems and security as they recover from the impact of COVID-19. Drawing on evidence-based and expert-validated interventions, it lays out a comprehensive series of measures policy makers could weave into national agendas. These range from steps to bolster health guidelines and ramp up testing and contact tracing to strategies that can improve community engagement and prevent misinformation. The guidance note discusses ways of addressing local gaps and priorities, responding to the destabilizing impact of the pandemic, and preparing for future outbreaks.