Generative Machine Learning Models in Medical Image Computing" provides a comprehensive exploration of generative modeling techniques tailored to the unique demands of medical imaging. This book presents an in-depth overview of cutting-edge generative models such as GANs, VAEs, and diffusion models, examining how they enable groundbreaking applications in medical image synthesis, reconstruction, and enhancement. Covering diverse imaging modalities like MRI, CT, and ultrasound, it illustrates how these models facilitate improvements in image quality, support data augmentation for scarce datasets, and create new avenues for predictive diagnostics. Beyond technical details, the book addresses critical challenges in deploying generative models for healthcare, including ethical concerns, interpretability, and clinical validation. With a strong focus on real-world applications, it includes case studies and implementation guidelines, guiding readers in translating theory into practice. By addressing model robustness, reproducibility, and clinical utility, this book is an essential resource for researchers, clinicians, and data scientists seeking to leverage generative models to enhance biomedical imaging and deliver impactful healthcare solutions. Combining technical rigor with practical insights, it offers a roadmap for integrating advanced generative approaches in the field of medical image computing.