This book presents research by African American, Latino/a/x, and Alaskan Indian/Native American (AI/AN) communication scholars. It highlights the importance of communication and the recognition of the unique experiences that impact how health information and health care are understood through diverse racial and cultural perspectives. Each chapter advances various divergent health issues and disparities pertinent to Black, Latino/a/x, and AI/AN communities, so that the powerful aspect of the human condition to know and be known as it relates to the negotiation of health and communication can be clearly understood. Contributions to this volume unabashedly call for more equitable, community-centric, tribally-centered, and transparent scholarship on topics of health disparities, health care, marginality, medical mistrust, social justice, and media and new technology as it relates to people of color. The authors in this book are committed to research areas that invigorate and reimagine conversations among clinicians, public health professionals, classroom environments, and communities. This insightful volume seeks to shift the dominant culture paradigms and locate authors of color and their research experiences and scholarship as central to their work. It provides a space to amplify the voices of our collective lived experiences through the vehicle of rigorous engaged scholarship. The book was originally published as a special issue of Health Communication.