This book provides a comprehensive history of the University of Pennsylvania from its founding in 1749 through the year 1827. The author, a former provost of the university, details the challenges and triumphs of this prestigious institution, including the establishment of the nation's first medical school and the construction of iconic campus landmarks. This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.