A common condition that occurs when tears are unable to provide adequate lubrication to the eyes is known as dry eye disease. This inability of tears may lead to inflammation and damage to the eye's surface. The common symptoms include eye discomfort, stinging or burning or scratchy sensation in eyes, stringy mucus in or around eyes, sensitivity to light, eye redness, etc. Other symptoms include difficulty wearing contact lenses, difficulty in driving at night, watery eyes, and blurred vision or eye fatigue. There are several causes for tear film dysfunction including hormone changes, autoimmune disease, inflamed eyelid glands, or allergic eye disease. Some other reasons such as decreased tear production or increased tear evaporation may also result in this condition. Preventive measures involve taking eye breaks during long tasks, avoiding smoking, and humidifying the air. This book is a compilation of chapters that discuss the most vital concepts and emerging trends in dry eye disease. It will help the clinicians in keeping pace with the rapid changes in its diagnosis and treatment.