This two-volume set LNCS 11581 and 11582 constitutes the thoroughly refereed proceedings of the 10th International Conference on Digital Human Modeling and Applications in Health, Safety, Ergonomics and Risk Management, DHM 2019, which was held as part of the 21st HCI International Conference, HCII 2019, in Orlando, FL, USA, in July 2019. The total of 1275 papers and 209 posters included in the 35 HCII 2019 proceedings volumes were carefully reviewed and selected from 5029 submissions. DHM 2019 includes a total of 77 papers; they were organized in topical sections named: Part I, Human Body and Motion: Anthropometry and computer aided ergonomics; motion prediction and motion capture; work modelling and industrial applications; risk assessment and safety. Part II, Healthcare Applications: Models in healthcare; quality of life technologies; health dialogues; health games and social communities.