Antibiotics are medications or substances that inhibit or slowdown the growth of bacteria by preventing the reproduction of bacteria. Antimicrobial resistance is a growing threat to public health, which includes the resistant strains of fungi, gram-positive bacteria, and anaerobic species. Additionally, it increases the deaths, length of stay in the hospital, and healthcare expenses for the public. Candida auris, staphylococcus aureus, clostridioides difficile, are some examples of fungi and bacteria that can cause various clinical diseases. The treatment of infections caused by antibiotic-resistant gram-negative aerobes is a major challenge in the field of public health. Recent research have led to the development of novel antibiotics useful in treating infections caused by resistant gram-negative organisms. These novel antibiotics include ceftolozane, avibactam, cefiderocol, plazomicin, meropenem, relebactam, eravacycline, and omadacycline. This book traces the current progress in antibiotics research. It presents researches and studies performed by experts across the globe. With state-of-the-art inputs from acclaimed experts in medical science, this book targets students and professionals in the field of antibiotics research.