This work provides starting guide for simple Postfix mail server configuration. Then I configured the Postfix mail server to support Anti-Spam and Anti-Virus, using two methods. Method 1: With Postfix, SpamAssassin, ClamAV and Amavis-new Method 2: With Postfix, SpamAssassin, ClamAV and Procmail The report includes the following sections How Postfix receives mail: How Postfix delivers mail Starting guide for quick Postfix configuration Postfix mail server and Dovecot configuration Installing ClamAV and SpamAssassin Installing and configuring Squirrelmail: Method 1 to support Antivirus and Antispam: Using Postfix, Amavis-new, ClamAV, SpamAssassin Method 2 to support Antivirus and Antispam: Using Postfix, Procmail, ClamAV, SpamAssassin