This book constitutes the refereed proceedings of the 25th International Workshop on Computer Algebra in Scientific Computing, CASC 2023, which took place in Havana, Cuba, during August 28-September 1, 2023.The 22 full papers included in this book were carefully reviewed and selected from 29 submissions. They focus on the theory of symbolic computation and its implementation in computer algebra systems as well as all other areas of scientific computing with regard to their benefit from or use of computer algebra methods and software.