This book includes selected papers from the 4th International Conference on Computational Vision and Bio Inspired Computing (ICCVBIC 2020), held in Coimbatore, India, from November 19 to 20, 2020. This proceedings book presents state-of-the-art research innovations in computational vision and bio-inspired techniques. The book reveals the theoretical and practical aspects of bio-inspired computing techniques, like machine learning, sensor-based models, evolutionary optimization and big data modeling and management that make use of effectual computing processes in the bio-inspired systems. As such it contributes to the novel research that focuses on developing bio-inspired computing solutions for various domains, such as human-computer interaction, image processing, sensor-based single processing, recommender systems and facial recognition, which play an indispensable part in smart agriculture, smart city, biomedical and business intelligence applications.