This book constitutes the proceedings of the 6th International Workshop on Computational Topology in Image Context, CTIC 2016, held in Marseille, France, in June 2016.The 24 papers presented in this volume were carefully reviewed and selected from 35 submissions. Additionally, this volume contains 2 invited papers. CTIC covers a wide range of topics such as: topological invariants and their computation, homology, cohomology, linking number, fundamental groups; algorithm optimization in discrete geometry, transfer of mathematical tools, parallel computation in multi-dimensional volume context, hierarchical approaches; experimental evaluation of algorithms and heuristics; combinatorial or multi-resolution models; discrete or computational topology; geometric modeling guided by topological constraints; computational topological dynamics; and use of topological information in discrete geometry applications.