With the conclusion of the Uruguay Round, the World Trade Organization was established as a fully-fledged international organization including a comprehensive dispute settlement system which has, however, recently been challenged. This commentary on the Agreement Establishing the WTO, the Dispute Settlement Understanding and the Trade Review Policy Mechanism offers a comprehensive overview of the legislative history, interpretation, practical application and challenges to the institutional system of the WTO. This volume brings together contributions by distinguished scholars and practitioners and aims at giving guidance to all interested in the WTO institutional arrangements and dispute settlement system.