Our bodies and brains are radically transformable, mutable and plastic. From the neuroplasticity of the brain to the epigenetic malleability of our bodies and of all organic life, the work of the contemporary French philosopher Catherine Malabou invites us to consider our plasticity as both a creative resource and an ethical challenge. This book brings Malabou’s philosophy into dialogue with contemporary literature and film. It reads conceptions of plasticity and neuroplasticity in Malabou through the mutant bodies of Leos Carax’s films; the shape-shifting bodies of Marie Darrieussecq’s novels and theatre; the terrifying, traumatic metamorphoses depicted in the fiction of Marie NDiaye; and the anarchic sexualities and identities celebrated in the cinema and writing of Alain Guiraudie. It argues that, in different ways, Malabou’s philosophy and literary and filmic texts develop modes of bearing witness to plasticity which can supplement, challenge and extend scientific understandings of biological plasticity, constituting ethical and creative sites of exploration.