The 4-volumes set of LNCS 13529, 13530, 13531, and 13532 constitutes the proceedings of the 31st International Conference on Artificial Neural Networks, ICANN 2022, held in Bristol, UK, in September 2022. The total of 255 full papers presented in these proceedings was carefully reviewed and selected from 561 submissions. ICANN 2022 is a dual-track conference featuring tracks in brain inspired computing and machine learning and artificial neural networks, with strong cross-disciplinary interactions and applications.