This book constitutes the proceedings of the 15th Italian Workshop on Artificial Life and Evolutionary Computation, WIVACE 2021, held in Winterthur, Switzerland, in September 2022.  The 14 full papers and 10 short papers presented in this volume were carefully reviewed and selected from 25 submissions. The papers are organized in the following topical sections: Networks; Droplets, Fluids, and Synthetic Biology; Robot Systems; Computer Vision and Computational Creativity; Semantic Search; Artificial Medicine and Pharmacy; Trade and Finance; Ethics in Computational Modelling. Chapters 4, 5, 6, 7, 22, and 24 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.