Amides refer to functional groups wherein a carbonyl carbon atom is connected by a single bond to a nitrogen atom, and either a hydrogen or a carbon atom. An amide bond refers to a type of peptide bond. The condensation of an amine and a carboxylic acid is the most common process for the creation of this type of bond. The high stability of amide bonds is due to their tendency to create a resonating structure which gives a double bond character to the amide CO-N bond. It also leads to a decrease in the rotation around the peptide bond. The creation of amide bonds is a fundamental reaction in chemistry that is used in the synthesis of polymers, peptides and food additives. Inert amide bonds can be activated through acyl, acyl addition, radical and decarbonylative pathways. This book aims to shed light on the concepts and reactions of amide bond activation. It presents researches and studies performed by experts across the globe. The extensive content of this book provides the readers with a thorough understanding of the subject.