This volume offers the first comprehensive study of the De Nola (Venice 1514), a hitherto underappreciated Latin text written by the Nolan humanist and physician Ambrogio Leone. Furnished with four pioneering engravings made with the help of the Venetian artist Girolamo Mocetto, the De Nola is an impressively rich and multifaceted text, which contains an antiquarian (and celebratory) study of the city of Nola in the Kingdom of Naples. By describing antiquities, inscriptions, and buildings, as well as social and religious phenomena, the De Nola offers a precious window into a southern Italian Renaissance city, and constitutes a refined example of sixteenth-century antiquarianism. The work is analysed in a multidisciplinary approach, encompassing art and architectural history, antiquarianism, literature, social history, and anthropology.