This book comprises select proceedings of the International Conference on Advances in Signal Processing and Communication Engineering (ICASPACE 2021). The book covers several theoretical and mathematical approaches addressing day-to-day challenges in signal, image, and speech processing and advanced communication systems. It primarily focuses on effective mathematical methods, algorithms, and models that enhance the performance of existing systems. The topics covered in the book are advances in signal processing (radar and biomedical), image processing, speech processing, technical and environmental challenges in 5G technology, and strategies for optimal utilization of resources to improve the efficacy of the communication systems in terms of bandwidth and radiating power, etc. The works published in the book will remarkably be helpful to prospective scholars, academicians, and students seeking knowledge in signal processing and communication engineering.