This Special Issue reprint focuses on innovations in glaucoma surgery. Glaucoma surgery continues to represent a real challenge both in terms of ensuring safety and efficacy, and particularly the balance between the two. Significant technological advances have led to innovative surgeries, which in turn have been rapidly introduced into clinical practice. Novel devices able to lower intraocular pressure are exhibiting promising results, but it remains unclear whether they can replace current 'standard' surgeries, such as trabeculectomy or glaucoma drainage devices. Moreover, even these standard procedures are being continuously modified in various ways in the search of enhanced safety-efficacy outcomes.